Although the physiological actions of angiotensin have attracted considerable interest, its effects on the maximal renal tubular transport rates for p-aminohippuric acid (PAH) and glucose (Tmpah and Tmg) have not previously been described in any species. This study therefore comprised an examination of Tmpah at three dose levels and Tmg at two dose levels of angiotensin. The Tm of neither substance was reduced. In the course of the experiments, glucose was found to elevate control PAH clearance measurements and to offer some protection against the renal vasoconstrictive effect of angiotensin. It was concluded that angiotensin does not cause focal renal cortical deprivation of blood flow, nor does it interfere with the tubular transport of PAH or glucose. Other aspects of the renal response to angiotensin are altered by glucose.
- PAH transport
- glucose transport
- angiotensin effect on renal function
- maximal tubular transport rates
With the Technical Assistance of Janusz B. Suszkiw
- Copyright © 1965 by American Physiological Society