The inhibitory effect of phlorizin and II phlorizin analogs on the active accumulation of glucose into pieces of hamster small intestine in vitro has been determined. Of all the compounds tested, phlorizin itself, at micromolar concentrations, was found to be the most potent inhibitor of glucose uptake. The less-active phlorizin congeners exhibited varying degrees of activity. Their order of effectiveness reported in an earlier in vivo study has been corroborated by the results of the present investigation.
- structure-activity relationship
- phlorizin and phlorizin analogs
- glucose transport site
- phlorizin receptor
- intestinal transport of glucose
- hamster small intestine
- Copyright © 1965 by American Physiological Society