The release of neurohumoral agents into the circulation following the administration of endotoxin has been studied. The use of the isolated vein in circuit with dogs administered a lethal dose of endotoxin permitted measurement of changes in vessel tension and afforded a continuous bioassay of the existing neurohumoral balance. Blocking agents were used to define the agent active at any one time. It appears that histamine or a compound similar to histamine is active in the first phase of shock, with catecholamines playing a predominant supportive role during the second hypotensive phase. The possibility of a parasympatheticlike response causing bradycardia and hypotension is also indicated.
- bioassay in shock
- blood vasoactive substances
- neurohumoral features of endotoxin shock
- gram-negative bacteremic shock
- Copyright © 1965 by American Physiological Society