A study was made of the effects of intravenous infusions of 100-ml hypertonic (ca. 2,400 mosmoles/kg) solutions of NaCl, mannitol, and glucose on blood and gastric juice of five dogs during histamine stimulation. These were compared to control studies in the same dogs in which no infusion was given or in which isotonic NaCl was infused. Hypertonic solutions, regardless of chemical nature, acutely elevated plasma osmolality by 18–24 mosmoles/kg, raised gastric juice [H+] by 7–10 mEq/liter and [Cl–] by 6–9 mEq/liter. The output of volume, H+, Cl–, and pepsin, however, was unaffected. In the light of these findings the osmolality of the gastric mucosa is judged to be isotonic with plasma and extremely sensitive to external osmotic changes.
- hypertonic NaCl
- hypertonic glucose
- hypertonic mannitol
- Copyright © 1964 by American Physiological Society