AJP Legacy

Normal blood clotting of inbred mice

Hans Meier, Robert C. Allen, Warren G. Hoag


Normal values for a variety of coagulation tests were comparable regardless of strains of mice or sex, suggesting lack of physiologic variation in factors, e.g., "antithromboplastins," inhibitors, etc. Units of mouse prothrombin per milliliter are only about one-half those of man; prothrombin is rapidly destroyed after coagulation, and in order to obtain consistent clotting of recalcified plasma, admixture of platelet factor reagent is necessary.