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Am J Physiol 231: 1750-1753, 1976;
0002-9513/76 $5.00
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American Journal of Physiology, Vol 231, Issue 6, 1750-1753
Copyright © 1976 by American Physiological Society

ARTICLES

Response to angiotensins I and II and to AI-converting-enzyme inhibitor in a shark

DF Opdyke and R Holcombe

The spiny dogfish shark, which does not have renal juxtaglomerular cells, exhibits a strong pressor response to both angiotensin I and II. A nonapeptide, angiotensin I-converting-enzyme inhibitor, blocks the pressor response to angiotensin I in this fish. The pressor response to both angiotensin II and norepinephrine is completely blocked by the adrenergic blocking drug phentolamine.


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