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Am J Physiol 230: 1349-1353, 1976;
0002-9513/76 $5.00
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American Journal of Physiology, Vol 230, Issue 5, 1349-1353
Copyright © 1976 by American Physiological Society

ARTICLES

Histidine decarboxylase-mediated histamine synthesis in glomeruli from rat kidneys

JI Heald and TM Hollis

Enzymatic histamine synthesis by renal glomeruli of the rat has been examined. Assays of the partially purified enzyme demonstrated a pH optimum of 6.2, a Michaelis-Menten constant of 2.4 X 10(-4) histidine, and lack of potentiation by benzene. These data thus indicate that renal glomeruli contain the histidine-specific histidine decarboxylase.




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Copyright © 1976 by the American Physiological Society.