| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ARTICLES |
Five rhesus monkeys were infused intravenously with partially purified cholecystokinin (CCK) Just prior to a test meal of solid food after overnight food deprivation; CCK produced large, rapid, dose related suppressions of feeding. The lowest dose tested (5 Ivy U/kg body wt) produced a significant inhibition of food intake (26% suppression, P less than 0.05). Equivalent infusions of partially purified CCK or the synthetic COOH-terminal octapeptide of CCK (a pure fragment with all the biological activity of the full molecule) produced equivalent suppressions. In a second experiment, gastric preloads of a potent releaser of endogenous CCK, L-phenylalanine (L-Phe), and a weak releaser, D-phenylalanine (D-Phe) were compared for their relative abilities to suppress food intake at a test meal in nine rhesus monkeys after overnight deprivation. L-Phenylalanine produced large, rapid, dose-related suppressions of feeding, but D-Phe did not. The threshold dose of L-Phe was 0.5 g/kg (32% suppression, P less than 0.01). Neither CCK nor L-Phe caused signs of illness in these experiments. The results demonstrate that intravenous exogenous CCK suppresses feeding in rhesus monkeys and suggest that endogenous CCK has the same effect; they are consistent with the hypothesis that CCK is a satiety signal.
This article has been cited by other articles:
|
|
 |
|
  R. D. Cone Studies on the Physiological Functions of the Melanocortin System Endocr. Rev., December 1, 2006; 27(7): 736 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bi, K. A. Scott, A. S. Kopin, and T. H. Moran Differential Roles for Cholecystokinin A Receptors in Energy Balance in Rats and Mice Endocrinology, August 1, 2004; 145(8): 3873 - 3880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. J. Ellacott, C. B. Lawrence, L. E. Pritchard, and S. M. Luckman Repeated administration of the anorectic factor prolactin-releasing peptide leads to tolerance to its effects on energy homeostasis Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1005 - R1010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Matzinger, L Degen, J Drewe, J Meuli, R Duebendorfer, N Ruckstuhl, M D'Amato, L Rovati, and C Beglinger The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans Gut, May 1, 2000; 46(5): 689 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Weller, G. Smith, and J Gibbs Endogenous cholecystokinin reduces feeding in young rats Science, March 30, 1990; 247(4950): 1589 - 1591. [Abstract] [PDF]
|
|
|
|
|
|
E Straus and R. Yalow Cholecystokinin in the brains of obese and nonobese mice Science, January 5, 1979; 203(4375): 68 - 69. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
