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Am J Physiol 209: 1295-1303, 1965;
0002-9513/65 $5.00
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Salicylate: effects on ion transport and afterpotentials in frog sciatic nerve

William P. Hurlbut 1

1 The Rockefeller Institute, New York City

Ten-millimolar sodium salicylate inhibits almost completely the active transport of Na and K in frog nerve. Salicylate slows and reduces, but does not prevent, the postanoxic hyperpolarization of the nerve fibers, and has little effect on posttetanic hyperpolarization. Although intracellular sodium is required to produce the postanoxic hyperpolarization, these results suggest that active transport of Na or K is not the basis of this requirement.

Key Words: frog nerve • anoxia

Submitted on June 24, 1965




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J. L. Barker and H. Levitan
Salicylate: Effect on Membrane Permeability of Molluscan Neurons
Science, June 18, 1971; 172(3989): 1245 - 1247.
[Abstract] [PDF]


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