AJP Legacy AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol 209: 1267-1277, 1965;
0002-9513/65 $5.00
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reis, D. J.
Right arrow Articles by Cuenod, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reis, D. J.
Right arrow Articles by Cuenod, M.

Central neural regulation of carotid baroreceptor reflexes in the cat

Donald J. Reis 1 and Michel Cuenod 1

1 Laboratory of Neurophysiology, Section of Limbic Integration and Behavior, National Institute of Mental Health, Bethesda, Maryland, and Department of Neurology, Cornell University Medical College, New York City

Reflex changes of the mean aortic blood pressure (BP) to carotid sinus stretch or carotid occlusion in anesthetized vagotomized cats were observed following ablation or electrical stimulation of brain. Decerebration produced augmentation of the depressor response to sinus stretch, reduction of the pressor response to carotid occlusion, and fall of BP. Subsequent cerebellectomy produced an increase of depressor and pressor responses. Midpontine section produced disappearance of the pressor response to carotid occlusion and appearance of a "paradoxical" pressor response to sinus stretch. Stimulation within hypothalamus and reticular formation produced augmentation and a barbiturate-sensitive poststimulus depression of pressor response without changes in BP. It is concluded that baroreceptor reflex responsiveness is under tonic and phasic control of brain structures above medulla and that pressor and depressor limbs of the reflex are not reciprocal and modified independently of each other and of the BP. This suggests functional separation of brainstem neurons involved in reflex and tonic BP control and that some cerebral regulation of BP is indirectly mediated through vascular reflexes.

Key Words: CNS and baroreceptor reflex • vagotomized cats • decerebration • cerebellectomy • pontine section • electrical stimulation • hypothalamus • reticular formation • depressor reflex • pressor reflex • arterial pressure • carotid occlusion

Submitted on February 19, 1965




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. Cui, S. Durand, and C. G. Crandall
Baroreflex control of muscle sympathetic nerve activity during skin surface cooling
J Appl Physiol, October 1, 2007; 103(4): 1284 - 1289.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Peyron, D. K. Tighe, A. N. van den Pol, L. de Lecea, H. C. Heller, J. G. Sutcliffe, and T. S. Kilduff
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
J. Neurosci., December 1, 1998; 18(23): 9996 - 10015.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
O. A. Smith Jr. and M. A. Nathan
Inhibition of the Carotid Sinus Reflex by Stimulation of the Inferior Olive
Science, November 4, 1966; 154(3749): 674 - 675.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 1965 by the American Physiological Society.