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Am J Physiol 209: 1213-1218, 1965;
0002-9513/65 $5.00
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Secretion of urea and thiourea in sweat

Saul W. Brusilow 1 and Ellen H. Gordes 1

1 Department of Pediatrics, Johns Hopkins University School of Medicine, and Harriet Lane Service, Johns Hopkins Children's Medical and Surgical Center, Baltimore, Maryland

The high sweat-to-serum urea ratio (greater than 1) was studied by correlating this ratio with serum urea concentration and sweat-to-serum osmolal ratios. In addition, the sweat-to-serum urea and thiourea ratios were studied in cat sweat as well as in human sweat. The results showed: 1) little relationship between sweat-to-serum urea ratios and sweat-to-serum osmolal ratios; 2) variable effects of serum urea concentrations on sweat-to-serum urea ratios; 3) sweat-to-serum thiourea ratios of 0.80 in man and in cats. These observations suggest that factors apart from back diffusion of water may account for some of the urea in sweat.

Key Words: sweat urea gradient • cat sweat • net urea movement • sweat osmolality

Submitted on May 21, 1965






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