Bone sodium as a function of serum sodium in rats

¹ Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York

In experiments of a few hours' duration, alterations in bone sodium induced by hypo- or hypernatremia were limited to that fraction contained in the fluid phase of bone, while acidosis per se produced no change (11, 14). The present report describes the results of chronic (5-day) hypo- and hypernatremia in the rat. Under these circumstances a change occurred in both the crystal and fluid Na of bone, and this change was proportional, and in the same direction, to that of serum Na. Young animals showed a greater change in bone Na than did adults. When hypertonic NH₄Cl was given for 5 days there was no evidence of mobilization of Na from bone, nor was Na stored when alkaline Na salts were administered. Bone Na reflects the concentration of this element in body fluids, and is not influenced by acid-base balance.

Key Words: hyponatremia • hypernatremia • acidosis • alkalosis

Submitted on March 1, 1965

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