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1 Shock Research Unit and Department of Medicine, University of Southern California School of Medicine, and Los Angeles County Hospital, Los Angeles, California
Corticosteroids administered in amounts more than 100 times those required to sustain a fully adrenalectomized animal were highly effective in increasing survival following hemorrhagic shock. In rats with intact adrenal glands, hemorrhagic shock was produced by maintaining arterial blood pressure at 35 mm Hg for 240 min. Glucocorticoids and aldosterone were administered only after blood was reinfused. The therapeutic benefit is due to a pharmacological action of the adrenocortical hormone. Aldosterone had a lesser and relatively narrow dosage range of effectiveness.
Key Words: bleeding • hemorrhage • aldosterone • cortisol • circulatory failure • hypotension • steroid
Submitted on March 22, 1965
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