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Am J Physiol 209: 702-704, 1965;
0002-9513/65 $5.00
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Effect of alpha-methyl-dopa on heart and pulmonary arteries of hypoxic mice

Richard L. Naeye 1

1 Department of Pathology, The University of Vermont College of Medicine, Burlington, Vermont

Fifty mice were placed in an atmosphere of 10% oxygen and sacrificed at intervals. Twenty-one of the animals were simultaneously given methyl-dopate-HCI. Hypoxic control mice developed medial hyperplasia in small pulmonary arteries and right ventricular cardiac hypertrophy. These abnormalities did not develop in the drug-treated animals.

Key Words: alpha-methyl-dopa and hypoxia • hypoxia and hypertension

Submitted on January 7, 1965






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