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Am J Physiol 209: 231-235, 1965;
0002-9513/65 $5.00
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Oxygen uptake and tetrazolium reduction during skin cycle of the mouse

Ira M. Dushoff 1, John Payne 1, Falls B. Hershey 1, and Robert C. Donaldson 1

1 Department of Surgery, Washington University School of Medicine, and John J. Cochran Veterans Administration Hospital, St. Louis, Missouri

Quantitative measurements of oxygen consumption and triphenyl tetrazolium chloride reduction by intact skin were made during various stages of the skin cycle of the mouse. Values are highest during early anagen, when growth is most rapid: Qo2 is 2.47 ± 0.10 (mean ± se) and TTC is 537 ± 24.6. In late anagen the activities decrease 40–50%: Qo2 is 1.24 ± 0.10 and TTC is 315 ± 20.8. There is a close relationship between tetrazolium reduction and oxygen consumption during all phases of the growth cycle of mouse skin. The coefficient of regression of TTC on Qo2 is 163.2 (P < .001).

Key Words: respiration of skin • skin metabolism • succinic dehydrogenase

Submitted on May 20, 1964







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