Transmucosal movement of selenium

¹ Radioisotope Service, Veterans Administration Hospital, and Department of Biochemistry, University of Louisville School of Medicine, Louisville, Kentucky

The transmucosal movement of selenium in the everted intestinal sacs of the golden hamsters was studied. The movement of selenium in the form of Na₂Se⁷⁵O₃, dl-seleno-75 cystine, l-seleno-75 methionine and dl-C¹⁴ methyl-labeled selenomethionine was examined. It was found that selenomethionine was transported against a concentration gradient, and selenite and selenocystine were not. The transport of l-selenomethionine is inhibited by the corresponding sulfur analogue, l-methionine. The transport of selenite and selenocystine were not inhibited by sulfite and cystine, respectively. Selenite, selenocystine, and selenomethionine in the concentration used did not inhibit the active transport of glucose.

Key Words: active transport of l-selenomethionine • intestinal absorption • golden hamster intestinal sac • amino acid transport • transmucosal movement of selenite, selenocystine, and selenomethionine • inhibition of selenium transport by sulfur analogue • mucosal active • transport system • glucose and selenium transport

Submitted on August 3, 1964

This article has been cited by other articles:

				J. W. Finley The Retention and Distribution by Healthy Young Men of Stable Isotopes of Selenium Consumed as Selenite, Selenate or Hydroponically-Grown Broccoli Are Dependent on the Isotopic Form J. Nutr., April 1, 1999; 129(4): 865 - 871. [Abstract] [Full Text]