| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York
The chronic ingestion of NH4Cl causes a true growth of the rat kidney. This involves a symmetrical increase in wet weight, dry weight, and nitrogen of the kidney tissue. Total DNA and RNA are also elevated, indicating that both cell numbers and cell size have increased. The renal hypertrophy in chronic metabolic acidosis is the same order of magnitude as that seen in the remaining kidney after unilateral nephrectomy. The renal growth-stimulating effects of acidosis and unilateral nephrectomy are additive. In the acidotic rat the renal hypertrophy that occurs after unilateral nephrectomy can maintain a high rate of ammonia excretion without any further change in renal glutaminase activity of the remaining kidney. Thus in certain species the stimulation of renal growth may play a part in the increasing capacity to excrete ammonia during sustained metabolic acidosis.
Key Words: glutaminase • RNA, DNA • unilateral nephrectomy • acid-base balance
Submitted on October 19, 1964
This article has been cited by other articles:
|
|
 |
|
  F. Turturro, R. Oliver III, E. Friday, I. Nissim, and T. Welbourne Troglitazone and pioglitazone interactions via PPAR-{gamma}-independent and -dependent pathways in regulating physiological responses in renal tubule-derived cell lines Am J Physiol Cell Physiol, March 1, 2007; 292(3): C1137 - C1146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. P. Curthoys, L. Taylor, J. D. Hoffert, and M. A. Knepper Proteomic analysis of the adaptive response of rat renal proximal tubules to metabolic acidosis Am J Physiol Renal Physiol, January 1, 2007; 292(1): F140 - F147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Oliver III, E. Friday, F. Turturro, A. Lacy, and T. Welbourne Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses Am J Physiol Renal Physiol, June 1, 2005; 288(6): F1257 - F1266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. FRANCH Modification of the Epidermal Growth Factor Response by Ammonia in Renal Cell Hypertrophy J. Am. Soc. Nephrol., September 1, 2000; 11(9): 1631 - 1638. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. D. Lotspeich Metabolic Aspects of Acid-Base Change Science, March 3, 1967; 155(3766): 1066 - 1075. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
