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Am J Physiol 208: 847-851, 1965;
0002-9513/65 $5.00
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Effect of urinary pH on the renal concentrating mechanism

Alvin Goodman 1 and Howard Levitin 1

1 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut

The influence of an alkaline urine on the maximum concentrating ability of the rat during antidiuresis and the Tch2o of dogs during osmotic diuresis was examined under conditions of alkali loading. In the rat, alkali loading induced an acute and reversible decrease in the maximum concentrating ability which could not be attributed to potassium deficiency or an associated increase in solute output. During osmotic diuresis in the dog, no change in the Tch2o accompanied alkalinization of the urine. It is suggested that the pCO2 of the urine plays an important role in determining the observed changes.

Key Words: urinary pCO2 • alkaline urine

Submitted on September 25, 1964






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