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Am J Physiol 207: 944-946, 1964;
0002-9513/64 $5.00
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Action current of striated muscle in heavy water

Howard Jenerick 1

1 Department of Physiology, Emory University, Atlanta, Georgia

The propagating spike potential of frog sartorius fibers recorded in H2O- and D2O-Ringer's fluids were compared. Negligible changes in the resting, spike, and afterpotential were seen. However, excitability was decreased and apparently caused a slowing of the conduction velocity. A differential effect on the inward and outward current was also observed. Whereas the inward current and conductance appeared completely independent of the solvent, the outward current was quite sensitive to D2O. It was reasoned that such behavior was more indicative of an ion exchange process for the action current in contrast to the conventional mechanism of parallel Na and K conductances.

Key Words: action potential • cell membrane • muscle fiber • D2O

Submitted on April 27, 1964






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