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Am J Physiol 207: 573-576, 1964;
0002-9513/64 $5.00
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Protection by restraint against parathyroid-extract intoxication in absence of the adrenals

H. Selye 1, G. Gabbiani 1, and B. Tuchweber 1

1 Institut de Médecine et de Chirurgie expérimentales, Université de Montréal, Montréal, Canada

Forced immobilization protected the rat against the soft-tissue calcinosis normally produced by large doses of parathyroid extract. This protection was evident even in adrenalectomized animals maintained on corticoids; indeed, in these, exposure to the severe stress of prolonged restraint actually counteracted the otherwise fatal effect of intense hyperparathyroidism.

Key Words: stress and hyperparathyroidism • calcinosis influenced by stress • hyperparathyroidism influenced by stress • cross resistance influenced by adrenalectomy

Submitted on January 16, 1964






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