Stimulation of sodium transport in toad bladder by acidification of mucosal medium

¹ Departments of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts
² Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts

The short-circuit current, sodium flux, and electrical potential across the isolated urinary bladder of the toad were stimulated by acidification of the medium bathing the mucosal or urinary surface of the bladder. By contrast the transport of chloride, potassium, urea, and water across the bladder was unaffected by similar acidification. The pH optimum for this action was approximately 5.5. The tissue pH, as determined by the distribution of DMO-C¹⁴, was not detectably affected by mucosal acidification.

Key Words: acidification and transport

Submitted on December 20, 1963

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