Effects of potassium on automaticity and conduction of canine hearts

¹ Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, New York

The action of potassium on cardiac automaticity and conduction was studied in dogs. It was found that idioventricular automaticity is depressed at an early stage of potassium administration. Apparent dissociation between P and QRS waves resulted from various degrees of atrioventricular block, but not complete block. The ventricles were driven by an atrial pacemaker even in absence of P waves in the limb lead ECG, as evidenced by the following findings. First, local atrial activity persisted in absence of P waves. Second, the His bundle electrogram maintained its control pattern. Finally, vagal stimulation inhibited the ventricular activity. Depression of ventricular conduction was found to involve Purkinje fibers, their junction with muscle, and the muscular fibers. Enlargement of the ventricular complexes in the ECG results in part from intermingling of depolarization and repolarization processes. Cardiac arrest results from failure of conduction since atrial activity often persisted after ventricular arrest. Ventricular flutter may occur in presence of reduced idioventricular automaticity; it is precipitated by a supraventricular beat under conditions of depressed ventricular conduction.

Key Words: potassium on heart • electrolytes • cardiac conduction • cardiac automaticity • atrioventricular block • ventricular flutter

Submitted on September 20, 1963

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				L. Gould, C. V. R. Reddy, and R. F. Gomprecht His Bundle Electrograms in a Patient With Hyperkalemia JAMA, October 7, 1974; 230(1): 87 - 88. [Abstract] [PDF]