Mercaptomerin effect on p-aminohippurate transport in man and pentobarbitalized dog

¹ Departments of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, and New York University School of Medicine, New York City

The effects of mercaptomerin on Tm_pah in man and the pentobarbital-anesthetized dog were studied by standard clearance methods. Tm_pah was depressed to 60% of control values during the 4th to 6th hr of pentobarbital anesthesia. Mercaptomerin administration to the pentobarbitalized dog prevented the depressant effect of pentobarbital on Tm_pah from appearing, in that no significant difference in Tm_pah was noted between control periods and postmercurial periods in these experiments. Injection of dimercaprol to pentobarbitalized animals receiving mercaptomerin depressed Tm_pah to values expected in anesthetized animals which had received no mercaptomerin. Dimercaprol had no effect in anesthetized animals not receiving mercaptomerin. In man, mercaptomerin depressed Tm_pah to 50% of control values whether the mercurial was injected before or after commencement of PAH-loading.

Key Words: pentobarbital-Tm_pah-dog • dimercaprol-Tm_pah-dog • anesthesia • barbiturates • renal function, man • renal function, dog • mercury • dimercaptopropanol • pentobarbital

Submitted on October 23, 1963