Hormonal effects on distribution and excretion of iodide-I¹³¹ in the dog

¹ McGill University Medical Clinic, Montreal General Hospital, Montreal, Canada

Studies of the kinetics of iodide-I¹³¹ given intravenously to control dogs and dogs receiving growth hormone, cortisone, and thyroxine showed that growth hormone and cortisone increased, whereas thyroxine decreased, the rate of urinary excretion of I¹³¹. By applying the kinetic analysis described previously it was found that the rates of distribution and excretion of iodide-I¹³¹ in the control and hormonal experiments were sufficiently rapid not to affect the interpretation of metabolic studies made with albumin-I¹³¹ in the dog. These results permit improved and more accurate estimates of the metabolism and distribution of plasma albumin in control dogs and dogs treated with the hormones.

Key Words: hormones and distribution and excretion of iodide-I¹³¹

Submitted on May 23, 1963