Metabolism and distribution of autologous and homologous albumin-I¹³¹ in the dog

¹ McGill University Medical Clinic, Montreal General Hospital, Montreal, Canada

Using autologous albumin labeled with I¹³¹, studies of the metabolism and distribution of plasma albumin were made in 11 healthy dogs maintained in nutritional balance. The average value for the transcapillary transport of plasma albumin (k₁x) was 2.59 g/day kg; for catabolic rate of plasma albumin (k₃x), 0.183 g/day kg; for the extravascular albumin (y), 1.48 g/kg; and for the intravascular albumin (x), 1.47 g/kg. The estimates of the foregoing with homologous albumin-I¹³¹ did not significantly differ. Results are also reported of the passage time distribution of the albumin flux through the interstitial fluids.

Key Words: metabolism and distribution of canine albumin

Submitted on May 23, 1963