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Am J Physiol 206: 926-928, 1964;
0002-9513/64 $5.00
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Coagulation factors in normal and hemophiliac-type swine

C. N. Cornell 1 and M. E. Muhrer 1

1 Departments of Agricultural Chemistry and Veterinary Physiology and Pharmacology, University of Missouri, Columbia, Missouri

A group of general coagulation tests and a specific assay for antihemophilic factor (AHF) was performed on five normal and two hemophiliac-type swine. There was no apparent evidence that an inhibitor of thromboplastin existed. Although the thromboplastin generation test was normal in all animals tested, a modified test employing a dilution technique demonstrated that a plasma abnormality existed in the hemophiliac-type swine. Serum from both normal and hemophiliac-type swine was found to correct the plasma recalcification time of human plasma known to be deficient in plasma thromboplastin component (factor IX). The results indicate that the hemophiliac-type swine are grossly deficient in AHF.

Key Words: antihemophilic factor (AHF, factor VIII) deficiency • thromboplastin inhibitor • hemophilia • hemostasis in swine

Submitted on September 9, 1963






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