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Am J Physiol 206: 887-890, 1964;
0002-9513/64 $5.00
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Tissue carbon dioxide stores: magnitude of acute change in the dog

S. F. Sullivan 1, R. W. Patterson 1, and E. M. Papper 1

1 Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York City

Carbon dioxide washout curves were determined in hyperventilated dogs. Direct measurement of mixed venous carbon dioxide tension allowed calculation of changes in whole-body CO2 stores. The average whole-body CO2 dissociation constant in ten studies was 3.73 ml/kg mm. The limiting factor in reaching a new steady-state value was represented by a slow compartment in the washout curve. The average rate constant for this compartment was 0.062 min–1. The slowest compartment in this analysis has a 98% change in 1 hr, therefore the experimentally determined whole-body dissociation constant should closely approximate actual changes in tissue CO2 stores, excluding bone and fat.

Key Words: CO2 washout curves • whole-body CO2 dissociation constant steady-state Pvco2

Submitted on April 29, 1963






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