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1 Department of Pathology, University of North Carolina, Chapel Hill, North Carolina
The technique of cross circulation was used to study antihemophilic factor (AHF) in normal and hemophilic dogs. Following cross circulation of 60 min, the plasma AHF of the hemophilic animals had increased to about 50% of the normal level. This increase was not accompanied by a corresponding decrease in the AHF in the plasma of the normal dog. In other experiments, splenectomized normal dogs were cross circulated with hemophilic dogs. Without a spleen, the normal dog was unable to maintain its plasma AHF during the shunting procedure. These studies indicate that the spleen is important in the homeostasis of antihemophilic factor.
Key Words: splenectomy • factor VIII • hemophilia
Submitted on August 26, 1963
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