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Am J Physiol 206: 251-254, 1964;
0002-9513/64 $5.00
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Distribution of thiocyanate between plasma and cerebrospinal fluid

E. Streicher 1, D. P. Rall 1, and J. R. Gaskins 1

1 Laboratory of Psychology, National Institute of Mental Health, and Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

Relatively small amounts of thiocyanate are found in the cerebrospinal fluid (CSF) at plasma levels below 1 mm/liter. Starting at plasma concentrations of about 1.5 mm/liter, a relatively constant plasma-CSF differential of approximately 1.2 mm/liter is established and maintained. This concentration difference, which essentially represents the "blood-CSF barrier" to thiocyanate is reversibly reduced by the intracisternal administration of hypertonic solutions.

Key Words: blood-cerebrospinal fluid barrier in dogs • modification of blood-cerebrospinal fluid barrier • cerebrospinal fluid thiocyanate

Submitted on October 18, 1962




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S. I. Rapoport, M. Hori, and I. Klatzo
Reversible Osmotic Opening of the Blood-Brain Barrier
Science, September 10, 1971; 173(4001): 1026 - 1028.
[Abstract] [PDF]


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