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Am J Physiol 206: 189-192, 1964;
0002-9513/64 $5.00
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Placental transfer of nitrofurantoin and furaltadone

James A. Buzard 1 and John D. Conklin 1

1 Eaton Laboratories Division, The Norwich Pharmacal Company, Norwich, New York

The placental transfer of nitrofurantoin and furaltadone was determined in the guinea pig, rabbit, dog, and sheep. Both compounds entered the fetal circulation of the dog to a greater extent than in the other species, and furaltadone consistently crossed the placenta more readily than nitrofurantoin in all species. On the basis of these results, it is suggested that the transplacental movement of drugs is determined by both the physical characteristics of the drug and the morphohistologic structure of the placenta.

Key Words: placental morphohistology and drug transfer • species specificity and placental transfer • guinea pig, rabbit, dog, sheep placentas • drug structure and placental transfer • membrane barriers • maternal-fetal exchange • fetal tissue metabolism of nitrofurans

Submitted on February 11, 1963






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Copyright © 1964 by the American Physiological Society.