Effect of bioflavonoids and methylprednisolone on collagen biosynthesis

¹ Department of Biochemistry and Nutrition, School of Dentistry, University of Southern California, Los Angeles, California

The administration of different citrus bioflavonoids to the rat failed to demonstrate anti-inflammatory effects when judged by their influence on the rate of collagen synthesis around subcutaneously implanted polyvinyl sponges. These compounds were administered orally, applied locally at the time of implantation, or injected either at the site of granulation or subcutaneously. Treatment with methylprednisolone (0.016 mg/day rat) retarded growth and inhibited collagen synthesis. However, bioflavonoids given to these animals were able to counteract partially or completely the inhibitory effects of the steroid on collagen formation. The efficacy of the bioflavonoid in this connection was related to its nature and route of administration.

Note:
With the Technical Assistance of Debbie Hom and Clearance Jones

Key Words: inflammation • corticosteroids

Submitted on March 6, 1963