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Am J Physiol 205: 902-904, 1963;
0002-9513/63 $5.00
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Effect of exercise and lactic acid infusion on individual free fatty acids of plasma

Martin Gold 1, Harvey I. Miller 1, B. Issekutz JR. 1, and John J. Spitzer 1

1 Department of Physiology, Hahnemann Medical College, and Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania

The effect of exercise and lactic acid infusion was studied in nonanesthetized dogs. Both procedures decreased the plasma free fatty acid level (FFA) as well as the concentration of the major individual fatty acids (palmitic, palmitoleic, stearic, oleic, and linoleic acids) of FFA. The percentage contribution of oleic and frequently of linoleic acid to the total FFA was also diminished after exercise or lactic acid infusion. Similar alterations in FFA were also observed due to Nembutal or morphine-chloralose anesthesia. The changes observed during exercise, or lactic acid infusion were similar to those produced by the administration of insulin or glucagon and opposite to those produced by epinephrine or norepinephrine.

Key Words: anesthesia

Submitted on March 1, 1963






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