Enzyme studies of skeletal muscle in mice with hereditary muscular dystrophy

¹ Institute of Psychiatric Research and Department of Neurology, Indiana University Medical Center, Indianapolis, Indiana

The activities of 20 enzymes in normal, heterozygous, and dystrophic mouse muscle were studied by means of quantitative microchemical methods. Enzyme activities in normal and heterozygous muscle were essentially the same. In dystrophic muscle glucose-6-P dehydrogenase, 6-P-gluconic dehydrogenase, glutathione reductase, peptidase, ß-glucuronidase, and glucokinase activities were significantly higher than in normal muscle, while -glycero-P dehydrogenase and lactic dehydrogenase activities were significantly lower. The pattern of enzyme activities found in normal gastrocnemius denervated by nerve section was strikingly similar to that in dystrophic muscle.

Key Words: quantitative histochemistry, muscle • myopathies • biochemical changes in muscular dystrophy • muscle metabolism

Submitted on May 20, 1963

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