| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York
The relation between arsenate and phosphate transport in the dog kidney was studied by measuring the renal clearance of arsenate labeled with its radioactive isotope As74. The experiments were performed during osmotic diuresis induced by mannitol. The results demonstrate certain similarities in the transport of these ions. Arsenate undergoes a net tubular reabsorption which is inhibited as the plasma phosphate concentration is raised. The inverse relationship between arsenate transport and the plasma As:P ratio suggests a competitive mechanism for the interaction between the two ions Like phosphate, arsenate transport is inhibited by glucose and this effect is reversed by phlorizin. An important difference between arsenate and phosphate transport is the sensitivity of arsenate transport to urine flow. In vivo reduction of arsenate to arsenite and a net tubular secretion of arsenite has been observed. The results are discussed in terms of the known ability of arsenate to substitute for phosphate in biochemical reactions.
Key Words: renal tubular transport • ion transport
Submitted on March 21, 1963
This article has been cited by other articles:
|
|
 |
|
  B. Nemeti, I. Csanaky, and Z. Gregus Effect of an Inactivator of Glyceraldehyde-3-Phosphate Dehydrogenase, a Fortuitous Arsenate Reductase, on Disposition of Arsenate in Rats Toxicol. Sci., March 1, 2006; 90(1): 49 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Nemeti and Z. Gregus Reduction of Arsenate to Arsenite by Human Erythrocyte Lysate and Rat Liver Cytosol - Characterization of a Glutathione- and NAD-Dependent Arsenate Reduction Linked to Glycolysis Toxicol. Sci., June 1, 2005; 85(2): 847 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Nemeti and Z. Gregus Glutathione-Dependent Reduction of Arsenate in Human Erythrocytes--a Process Independent of Purine Nucleoside Phosphorylase Toxicol. Sci., December 1, 2004; 82(2): 419 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Nemeti, I. Csanaky, and Z. Gregus Arsenate Reduction in Human Erythrocytes and Rats--Testing the Role of Purine Nucleoside Phosphorylase Toxicol. Sci., July 1, 2003; 74(1): 22 - 31. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
