AJP Legacy Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol 205: 499-503, 1963;
0002-9513/63 $5.00
This Article
Right arrow Full Text (PDF)
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Skinner, N. S.
Right arrow Articles by Sarnoff, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Skinner, N. S., JR.
Right arrow Articles by Sarnoff, S. J.

Hemodynamic effects of altering the timing of atrial systole

N. Sheldon Skinner JR. 1, Jere H. Mitchell 1, Andrew G. Wallace 1, and Stanley J. Sarnoff 1

1 Laboratory of Cardiovascular Physiology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

The use of heart block dog preparations allowed an investigation at constant ventricular rates of the hemodynamic effects which resulted when the timing of atrial systole was altered relative to ventricular systole. Ganglionic blockade and vagotomy precluded sympathetic reflex compensation in these animals. Lengthening or shortening the interval between left atrial and left ventricular systole (As-Vs interval) produced a decrease in left ventricular end-diastolic pressure (LVEDP), mean aortic pressure, and aortic flow. Mean left atrial pressure (MLAP) increased as did the relation of MLAP to LVEDP. The absence of atrial systole produced similar changes. Lengthening or shortening the As-Vs interval while holding aortic pressure and stroke volume constant resulted in an increase in MLAP and the relation of MLAP to LVEDP. The changes observed in the left atrial pressure tracings suggested and a platinum electrode technique demonstrated that mitral regurgitation can occur with improper timing of atrial systole. The data indicate that properly timed, effective atrial activity can enhance ventricular filling and can preclose the atrioventricular valve.

Submitted on April 9, 1963




This article has been cited by other articles:


Home page
 CirculationHome page
S. F. Noujaim, E. Lucca, V. Munoz, D. Persaud, O. Berenfeld, F. L. Meijler, and J. Jalife
From Mouse to Whale: A Universal Scaling Relation for the PR Interval of the Electrocardiogram of Mammals
Circulation, November 2, 2004; 110(18): 2802 - 2808.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
M. C. Porciani, A. Sabini, A. Colella, A. Michelucci, N. Musilli, P. Pieragnoli, and L. Padeletti
Interatrial septum pacing avoids the adverse effect of interatrial delay in biventricular pacing: an echo-Doppler evaluation
Europace, January 1, 2002; 4(3): 317 - 324.
[Abstract] [PDF]

Home page
 ANGIOLOGYHome page
A. Ronaszeki, B. Denef, H. Ector, A. E. Aubert, F. Van de Werf, and H. De Geest
Influence of Short Atrioventricular Delay on Late Diastolic Transmitral Flow and Stroke Volume
Angiology, January 1, 1992; 43(1): 32 - 39.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 1963 by the American Physiological Society.