Gastric secretogogues in postprandial thoracic duct lymph

¹ Department of Surgery, University of Washington School of Medicine, Seattle, Washington

Fasting and postprandial thoracic duct lymph was collected from Heidenhain pouch dogs. When autogenous lymph was returned intravenously, postprandial samples stimulated pouch acid output, whereas fasting ones did not. The gastric secretogogues were more active in lymph collected 2–4 hr postprandially than 0–2 hr. After ultracentrifugal separation, both fatty and clear fractions of postprandial lymph contained gastric secretogogues. These stimulatory factors were not present in either clear or fatty fractions of lymph after antrectomy. Histamine was not the gastric secretogogue involved here. The gastric secretogogue present in postprandial lymph may be antral gastrin.