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Am J Physiol 205: 49-52, 1963;
0002-9513/63 $5.00
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Effects of intense or prolonged stimulation on systole

H. Mazzella 1

1 Departamento de Fisiologia, Facultad de Medicina, Montevideo, Uruguay

The mechanical effects of prolonged and intense d-c pulses were studied in the toad heart. Both potentiation and depression of systole were observed, the result being, in general, dependent upon pulse polarity. The potentiation was markedly diminished in hearts from reserpinized and from sympathectomized animals, while the depressant effect was not susceptible to atropine. It is concluded that the inotropic actions of high-voltage pulses are mediated by two effects; one, as yet ill-defined, on the membrane excitation process and one by catecholamine release from the myocardium.

Submitted on January 23, 1963






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