Effect of exercise on the metabolism of fatty acids in the dog

¹ Division of Research, Lankenau Hospital, Philadelphia, Pennsylvania

Dogs with indwelling arterial and venous catheters worked on a treadmill for 25–30 min. Exercise decreased the plasma free fatty acid (FFA) concentration and increased the blood glucose. In the postexercise period, the plasma inorganic P showed a significant decrease. Experiments with C¹⁴-palmitate and C¹⁴-oleate showed that the decrease of the plasma FFA was due partly to an elevated uptake and partly to a reduced rate of release into the blood. Infusions of Na lactate to resting dogs induced a marked increase in specific activity of plasma FFA, due to an inhibition of release. In spite of the reduced rate of release of FFA, the oxidation of the C¹⁴-fatty acid was considerably increased during exercise (three- to fourfold). No direct relationship seems to exist between the turnover rate of plasma FFA and the rate of oxidation of fatty acids.

This article has been cited by other articles:

				S. M. Gustavson, C. A. Chu, M. Nishizawa, B. Farmer, D. Neal, Y. Yang, E. P. Donahue, P. Flakoll, and A. D. Cherrington Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog Am J Physiol Endocrinol Metab, April 1, 2003; 284(4): E695 - E707. [Abstract] [Full Text] [PDF]

				R. C. Hill The Nutritional Requirements of Exercising Dogs J. Nutr., December 1, 1998; 128(12): 2686S - 2686. [Abstract] [Full Text]