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Am J Physiol 204: 975-978, 1963;
0002-9513/63 $5.00
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Effect of ryanodine on cardiac muscle

Winifred G. Nayler 1

1 Baker Medical Research Institute, Melbourne, Australia

Ryanodine (1 x 10–8 m) exerted a negative inotropic effect on toad ventricular muscle. The amplitude of contractions recorded from ryanodine-depressed ventricles were enhanced by raising the rate of stimulation, by increasing the extracellular Ca++ concentration, and by the addition of caffeine. The negative inotropic effect of ryanodine was reversed following perfusion with Tyrode solution containing 4 mm ethylenediaminetetraacetic acid.

Submitted on October 5, 1962






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