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1 Department of Zoology, Duke University, Durham, and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina
Fluid was collected by micropuncture from proximal and distal convolutions of anesthetized rats and analyzed for inulin, sodium, urea, and total osmotically active solute. The proximal fluid/plasma (F/P) sodium ratio was not significantly different from unity in antidiuretic animals, but was as low as 0.78 during mannitol diuresis. The distal F/P sodium ratio averaged 0.62 in antidiuresis, and 0.24 during osmotic diuresis. The data are interpreted to indicate active sodium transport by both proximal and distal convolutions. The F/P ratios for inulin, urea, and total osmotically active solute are in general agreement with previous studies.
Submitted on September 7, 1962
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