Water uptake in the intact frog

¹ Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut

The effects of potassium depletion, calciferol-induced hypercalcemia, hyaluronidase, hypercapnia, and adrenal steroids on the water uptake of intact frogs were studied. The findings suggest that potassium depletion and hypercalcemia interfere with water uptake. Hyaluronidase and adrenal glucocorticoids in doses used were without effect on water transport. Water uptake after oxytocin was greatly decreased by exposing frogs to a high concentration of CO₂ in air. The data obtained with frog skin in vivo are discussed in relation to in vitro studies with anuran membranes reported by others.