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Am J Physiol 204: 45-46, 1963;
0002-9513/63 $5.00
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In vitro antifibrinolytic activity of various compounds

Fred S. Barr 1, B. J. Brent 1, and D. Frank Holtman 1

1 Department of Bacteriology, University of Tennessee, Knoxville, Tennessee

Adrenochrome monosemicarbazone, vitamin C, nicotinic acid, epsilon aminocaproic acid, 4-aminobutyric acid, sodium salicylate, and adrenochrome isonicotinic acid hydrazone were tested for antifibrinolytic activity in vitro. Adrenochrome monosemicarbazone, epsilon aminocaproic acid, 4-aminobutyric acid, and adrenochrome isonicotinic acid hydrazone were found to exert an antifibrinolytic effect. Vitamin C was considered to have minimal effect and nicotinic acid and sodium salicylate were ineffective.

Submitted on May 17, 1962






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