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Am J Physiol 204: 1-4, 1963;
0002-9513/63 $5.00
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Ventricular distensibility and pressure-volume curve during sympathetic stimulation

Edmund H. Sonnenblick 1, John H. Siegel 1, and Stanley J. Sarnoff 1

1 Laboratory of Cardiovascular Physiology, National Heart Institute, Bethesda, Maryland

Experiments with an isovolumically contracting canine left ventricle preparation do not indicate that sympathetic cardiac nerve stimulation induces any alteration in ventricular distensibility. If the heart rate is sufficiently high to produce incomplete ventricular relaxation, sympathetic stimulation, by shortening systole, restores the relaxed pressure-volume relation without any indication, however, that ventricular distensibility is changed.

Submitted on July 2, 1962






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