Epinephrine release and liver glycogen levels after carbon tetrachloride administration

¹ Department of Biochemistry, McGill University, Montreal, Quebec, Canada

Two hours after the intraduodenal administration of carbon tetrachloride to rats, a decrease in the adrenal epinephrine level was detected, with a concomitant increase in serum epinephrine level. A simultaneous rise in liver phosphorylase activity and blood glucose concentration was seen. Two hours later these values all had returned to normal. Depletion of liver glycogen and increase in serum transaminase were noted 7 hr after CCl₄ administration. Ergotamine could diminish the depletion of glycogen but had no effect on transaminase activity. Phenoxybenzamine did not inhibit liver glycogen depletion, but significantly decreased the transminase activity. Both antiadrenergic drugs were injected 1 hr after CCl₄ administration. These results indicate that release of epinephrine due to the administration of CCl₄ occurs much earlier than the 20-hr period previously reported. Decrease in the resultant depletion of glycogen had no effect on the increase in liver damage.

This article has been cited by other articles:

				R. D. Green III and J. W. Miller Catecholamine Concentrations: Changes in Plasma of Rats during Estrous Cycle and Pregnancy Science, February 18, 1966; 151(3712): 825 - 826. [Abstract] [PDF]