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Am J Physiol 203: 685-686, 1962;
0002-9513/62 $5.00
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Oxytocic action of arachidonic acid under different hormonal environments

Shigetaka Ichikawa 1 and Jiro Yamada 1

1 Department of Veterinary Science, College of Agriculture, University of Osaka Prefecture, Sakai, Osaka, Japan

The minimum effective doses of oxytocin and arachidonic acid to produce contractions of pregnant and estrous rat uteri were determined. The pregnant rat uteri were significantly less sensitive to oxytocin and more sensitive to arachidonic acid than the estrous uteri. This mode of action of arachidonic acid on the uterine musculature indicates that the fatty acid may serve as an oxytocic substance for parturition.

Submitted on March 17, 1961






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