Catecholamine content of various organs in experimental hypertension

¹ Department of Medicine, Wayne State University College of Medicine, and Harper Hospital, Detroit, Michigan

Nephrogenic hypertension in dogs produced by a unilaterally placed Goldblatt clamp resulted in diminished catecholamine content in the thoracic aorta, both kidneys, and in the spleen. The catecholamine content in heart, brain, and the adrenal glands remained unaffected. Neurogenic hypertension, induced by partial section of buffer nerves, had no significant effect on the catecholamine content of these organs. The influence of the two types of hypertension on sympathetic activity, catecholamine synthesis, and release are discussed.