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Am J Physiol 203: 389-390, 1962;
0002-9513/62 $5.00
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Failure to show change in rat tissue histamine and serotonin after rapid decompression

Eric P. Kindwall 1, Lars Olof Boréus 1, and Barbro Westerholm 1

1 Laboratories of Aviation and Naval Medicine; Department of Physiology and Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden

Albino rats were subjected to rapid decompression from high ambient pressure (6 atm). The mean levels of histamine and 5-hydroxytryptamine in skin, ileum, lung, and brain were measured. They showed no significant change as compared to a nondecompressed control group even when decompression time was short enough to cause immediate death. The decompression also failed to produce any changes in the morphological appearance of the mesenteric mast cells.

Submitted on February 16, 1962






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