Hexose transport by hamster intestine in vitro

¹ Departments of Medicine and Biochemistry, Western Reserve University, Cleveland, Ohio; and Department of Physiology, Harvard Medical School, Boston, Massachusetts

The ability of everted sacs of hamster intestine to concentrate 18 glycosides and 5-deoxyglucose was determined. It was concluded that most of the glycosides were actively transported, but the nature of the aglycone is an important determinant in the extent of transport. A pyranose configuration is required of a sugar if it is to be transported. Evidence was also obtained which indicates that the carbon-to-hydrogen bonds of carbon 1 and 6 of glucose are transported intact. Therefore, the occurrence during transport of a reaction in which either of these bonds is cleaved appears unlikely.

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With the Technical Assistance of Angela DeCarlo

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