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Am J Physiol 202: 1152-1154, 1962;
0002-9513/62 $5.00
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Influence of monoamine oxidase inhibitor on contractility of isolated rat hearts

F. L. Meijler 1 and D. Durrer 1

1 University Department of Cardiology and Clinical Physiology, Wilhelmina Gasthuis, Amsterdam, the Netherlands

Following the suggestion that monoamine oxidase inhibitor might interfere with potentiation of cardiac contractions, the influence of 1-iso-nicotinyl-2-isopropyl-hydrazide and 1-pivaloyl-2-benzyl-hydrazine on postextrasystolic increase of isotonic contractions in isolated perfused rat hearts was studied. It was found that monoamine oxidase inhibitor did not change the increase in contractility following an interpolated or a noninterpolated premature beat. The metabolic process by which cardiac muscle varies its contractility with varying cycle length remains unknown.

Submitted on November 15, 1961






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