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Am J Physiol 202: 1136-1140, 1962;
0002-9513/62 $5.00
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Renal tubular transport of nitrofurantoin

James A. Buzard 1, Raymond C. Bender 1, Esther G. Nohle 1, Donald T. Humphrey 1, and Mary F. Paul 1

1 Biochemistry Section, Eaton Laboratories, Division of The Norwich Pharmacal Company, Norwich, New York

Tubular secretion of nitrofurantoin has been demonstrated in the dog and the chicken. This secretion has been localized in the proximal tubule and has been shown to be due to the action of the weak acid transport system. Reabsorption of nitrofurantoin by passive, nonionic diffusion has also been illustrated.

Submitted on December 4, 1961






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